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  • Term: morphine withdrawal
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    morphine withdrawal!


    morphine withdrawal

    Comprehensive Analysis



    1) "Morphine" -- As to morphine withdrawal

    mor·phine
    Pronunciation: 'mor-"fEn
    Function: noun
    Etymology: French, from Morpheus
    : a bitter crystalline addictive narcotic base C17H19NO3 that is the principal alkaloid of opium and is used in the form of a soluble salt (as a hydrochloride or a sulfate) as an analgesic and sedative
    Pronunciation Symbols

    This article is about the opiate. See Morphine (band) for information about the alternative rock group.
    Systematic (IUPAC) name
    7,8-didehydro-
    4,5-epoxy-17-methylmorphinan-3,6-diol
    Identifiers
    CAS number 57-27-2
    ATC code N02AA01
    PubChem 5288826
    DrugBank APRD00215
    Chemical data
    Formula C17H19NO3 
    Mol. mass 285.4
    Pharmacokinetic data
    Bioavailability ~30%
    Protein binding 30–40%
    Metabolism Hepatic 90%
    Half life 2–3 hours
    Excretion Renal 90%, biliary 10%
    Therapeutic considerations


    2) "Withdrawal" -- As to morphine withdrawal

    with·draw·al
    Pronunciation: -'dro(-&)l
    Function: noun
    1 a : the act of taking back or away something that has been granted or possessed b : removal from a place of deposit or investment c (1) : the discontinuance of administration or use of a drug (2) : the syndrome of often painful physical and psychological symptoms that follows discontinuance of an addicting drug <a heroin addict going through withdrawal>
    2 a : retreat or retirement especially into a more secluded or less exposed place or position b : an operation by which a military force disengages from the enemy c (1) : social or emotional detachment (2) : a pathological retreat from objective reality (as in some schizophrenic states)
    3 : RETRACTION, REVOCATION <threatened us with withdrawal of consent>
    4 a : the act of drawing someone or something back from or out of a place or position b : COITUS INTERRUPTUS
    Pronunciation Symbols

    For other meanings, see Withdrawal (disambiguation).

    Withdrawal also known as withdrawal syndrome, refers to the characteristic signs and symptoms that appear when a drug that causes physical dependence is regularly used for a long time and then suddenly discontinued or decreased in dosage. The term can also, less formally, refer to symptoms that appear after discontinuing a drug or other substance (unable to cause true physical dependence) that one has become psychologically dependent upon.

    • 1 Overview
    • 2 Withdrawal from drugs of abuse
    • 3 Withdrawal from prescription medicine
    • 4 Rebound
    • 5 See also
    • 6 Literature
    • 7 External links

    The sustained use of many kinds of drugs causes reversible adaptations within the body that tend to lessen the drug's original effects over time, a phenomenon known as drug tolerance. To have these adaptations to a drug is to have a physical dependency on it, for when the drug is suddenly discontinued or decreased, the adaptations do not immediately disappear. Unopposed by the drug, the adaptations appear as withdrawal signs and symptoms that are generally the opposite of the drug's direct effects. Depending primarily on the drug's elimination half-life, withdrawal symptoms can appear within a few hours to several days after discontinuation.

    The withdrawal symptoms associated with many recreational drugs are well-known. However, many drugs that do not generally cause euphoria, and are therefore not generally abused or thought of as addictive, also induce physical dependence with associated withdrawal. Examples include beta blockers, corticosteroids such as cortisone, many anticonvulsants and most antidepressants. Nevertheless, sudden withdrawal from these medications can be harmful or even fatal; this is why many prescription labels explicitly warn the patient not to discontinue the drug without doctor a..."



    Further Data On Term for morphine withdrawal

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